Possible food and drug interactions when taking Mexitil

Consumer Information (PDR)

If Mexitil is taken with certain other drugs, the effects of either may be increased, decreased, or altered. It is especially important that you consult with your doctor before taking any of the following:

Antacids such as Maalox
Caffeine products such as No-Doz
Cimetidine (Tagamet)
Other antiarrhythmic drugs such as Norpace and Quinidex
Phenobarbital
Phenytoin (Dilantin)
Rifampin (Rifadin)
Theophylline products such as Theo-Dur

Consumer Information (Cerner Multum)

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For mexiletine, the following should be considered:

Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to mexiletine, lidocaine, or tocainide. Also tell your health care professional if you are allergic to any other substance, such as foods, preservatives, or dyes.

Pregnancy—Mexiletine has not been studied in pregnant women. However, studies in animals have shown that mexiletine causes a decrease in successful pregnancies but no birth defects. Before taking this medicine, make sure your doctor knows if you are pregnant or if you may become pregnant.

Breast-feeding—Mexiletine passes into breast milk. Because this medicine may cause serious side effects, breast-feeding is generally not recommended while you are receiving it. Be sure you have discussed this with your doctor before taking mexiletine.

Children—Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of mexiletine in children with use in other age groups.

Older adults—Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of mexiletine in the elderly with use in other age groups.

Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your health care professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Smoking may decrease the effects of mexiletine.

Other medical problems—The presence of other medical problems may affect the use of mexiletine. Make sure you tell your doctor if you have any other medical problems, especially:

• Congestive heart failure or
• Low blood pressure—Mexiletine may make these conditions worse

• Heart attack (severe) or
• Liver disease—Effects may last longer because of slower removal of mexiletine from the body

• Seizures (history of)—Mexiletine can cause seizures